Development and validation of area under curve spectrophotometry method for ternary mixture of dextromethorphan HBr, doxylamine succinate and pseudoephedrine HCl in tablet dosage form

This study aimed to develop spectrophotometry method using area under curve determine the levels of dextromethorphan HBr (DMP), doxylamine succinate (DOX) and pseudoephedrine HCl (PSE) in tablet dosage form ethanol as solvent. The is based on AUC absorption measurement wavelength ranges 273-283 nm for DMP, 262-272 DOX 251-261 PSE. Then, was applied PSE form. selection wavelengths gives best result. mean % recoveries were found be 100.89%, 100.52%, 100.69% PSE, respectively. successfully analyze pharmaceutical formulation with no interference from excipients indicated by recovery study. All validation parameters within acceptable range.